Repository for Antibody Incompatible Transplantation Evidence

Renal transplantation performed across a positive crossmatch: a single centre experience

Ir J Med Sci. 1997 Oct-Dec;166(4):245-8 doi: 10.1007/BF02944244.

The importance of certain positive crossmatches (CM+) in kidney transplantation remains controversial. Fifty consecutive kidney transplants were performed across a CM+ between Jan. 1990-April 1994. In 19 cases there was an isolated B-cell CM+ (Group I), in 24 an historic T-cell IgM CM+ (Group II) and in 7 an historic T-cell IgG CM+ (Group III). Comparing groups I:II:III: early acute rejection affected 32%, 42%, 57% of grafts; mean serum creatinine at 3 months was 166, 150, 229 umol/l (p < 0.05); 1 yr graft survival was 95 per cent, 96 per cent, 71 per cent (p = 0.09). In group III both graft losses were in the setting of an additional current B-cell CM+.


Transplantation performed in either the presence of an isolated B-cell CM+ or in the presence of an historic T-cell IgM CM+ was associated with acceptable outcomes at 1 yr. An historic T-cell IgG CM+ was confirmed as a contraindication to transplantation in most circumstances, especially when coupled with a current B-cell CM+.

LEVEL OF EVIDENCE: Case Series / Case Control / Cohort
MESH HEADINGS: Adult; B-Lymphocytes; Contraindications; Female; Graft Rejection; Histocompatibility Testing; Humans; Immunoglobulin G; Immunoglobulin M; Kidney Function Tests; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; T-Lymphocytes; Treatment Outcome